The duration and severity of discontinuation symptoms, including "brain zaps," can vary significantly from person to person. The experience of withdrawal symptoms after discontinuing Prozac (fluoxetine) and starting Wellbutrin (bupropion) may depend on several factors, including the individual's unique biology, the duration of Prozac use, the dosage of Prozac, the rate of tapering, and how the body responds to the new medication.
In some cases, discontinuation symptoms from Prozac can occur after even a few missed doses or a rapid taper, while others may not experience significant withdrawal effects. Additionally, starting Wellbutrin may also introduce some adjustment effects, which could be mistaken for withdrawal symptoms.
That being said, the half-life of Prozac is relatively long (around 4-6 days), which means it stays in the body for a significant period after stopping the medication. Gradual tapering, under the supervision of a healthcare professional, can help reduce the risk of severe discontinuation symptoms.
On the other hand, Wellbutrin is less likely to cause withdrawal symptoms compared to SSRIs like Prozac, but some people may still experience initial side effects or adjustments as their body adapts to the new medication.
The timeline for discontinuation symptoms can vary, but they generally occur within a few days to a couple of weeks after reducing or stopping Prozac. They may last for a few days to several weeks, and in rare cases, some individuals may experience symptoms for a few months.
It's essential to work closely with your prescribing doctor throughout the transition from Prozac to Wellbutrin. They can provide guidance, monitor your progress, and adjust the dosage or approach if needed to help minimize any discomfort or potential withdrawal effects. If you experience any concerning symptoms during this period, make sure to inform your healthcare provider promptly for proper evaluation and support.